Abstract
The long-term goal of the proposed research is to characterize the function of the motif (“M-domain”) of cardiac myosin binding protein C (cMyBP-C) in damping spontaneous oscillatory contractions (SPOC) in skinned cardiomyocytes. The motif aids in binding of cMyBP-C to both myosin and actin, and changes to its phosphorylation affect cMyBP-C affinity for both. Reduced phosphorylation of the motif is common in many cases of hypertrophic cardiomyopathy (HCM), and cMyBP-C mutations that reduce cMyBP-C expression are present in approximately 50% of cases of HCM.
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