Abstract
Lung function in humans during exercise has usually been regarded as well maintained, or even improved, compared with rest. Recent data, however, document considerable gas exchange inefficiency during very heavy work by well-trained normal subjects, and even more so when world-class athletes exercise maximally. Ascent to altitude clearly accentuates these problems. The deterioration of gas exchange seems to be caused mostly by failure of equilibration by diffusion of oxygen between alveolar gas and end-capillary blood.
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