The lowest effective dose of botulinum toxin in detrusor sphincter dyssynergia

Abstract

Detrusor sphincter dyssynergia is a spastic condition due to lack of coordination between the bladder and the external sphincter. It results in excessive bladder pressures and inability to empty the bladder completely. Botulinum toxin type A has been injected either transurethrally via cystoscope or transperineally under electromyographic control. The dose and dilution volume vary from author to author. This was a prospective, randomized, double-blind, dose-ranging clinical trial to define the lowest effective dose of botulinum toxin type A and safety in the treatment of detrusor sphincter dyssynergia. Twelve adult patients with detrusor sphincter dyssynergia are randomly divided into three groups by a random table, four patients in each group. Depending on randomization, BOTOX 50,75 or 100 U will be administered. The results indicate that BOTOX 75 and 100 U statistically reduce postvoiding residual urine and detrusor pressure at P Conclusion:The lowest effective dose of BOTOX in the treatment of detrusor sphincter dyssynergia is 75–100 U, which is slightly lower than in other studies.