Abstract
AIMS:This study was designed to determine the prevalence of azoospermia factor (AZF) microdeletions on the Y chromosome in Sri Lankan Sinhalese infertile men with azoospermia and severe oligozoospermia.SETTINGS AND DESIGN:The patient group was 207 karyotypically normal infertile Sinhalese males.MATERIALS AND METHODS:The presence of 13 sequence-tagged site (STS) markers in the AZF region was tested using multiplex polymerase chain reaction (M-PCR). One hundred and twenty unselected men were also studied as a control group.RESULTS:Three (1.5%) had classic Y chromosome microdeletions in the AZFc sub-region.CONCLUSIONS:These results suggest a much lower Y chromosome microdeletion frequency than previously thought, even among a strictly selected group of sub-fertile males in Sri Lanka.
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