Abstract
Myocardial ischemia is accompanied by the loss of copper. The present study was undertaken to understand the relationship between copper loss and alterations in copper efflux transporters. Male mice (C57 BL/6J) were subjected to left anterior descending artery (LAD) ligation to induce myocardial ischemia. The heart was harvested at different time points after the operation. Copper concentration in the heart was measured by atomic absorption spectrometry (AAS). Copper metabolism MURR1 domain (COMMD‐1) mRNA and protein levels were determined by RT‐PCR and western blot. Copper concentrations in the infarct area were decreased at the 4th day after ischemia, and further decreased thereafter. Prior to the gradually decreasing in copper concentrations, COMMD‐1 protein level was significantly increased at the 1st day in the infarct area. The result suggests that during the process of myocardial infarction, COMMD‐1 might play a key role in the loss of copper.Support or Funding InformationThis study is supported by National Science Foundation of China (81230004).
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