Abstract
DNA loops can be formed by a mechanism in which the cohesin complex pulls DNA strands through its ring structure using biased Brownian motion.
Highlights
Related research article Higashi TL, Tang M, Pobegalov G, Molodtsov M, Uhlmann F. 2021
How are very long strands of genomic DNA stored in a tiny cell? In eukaryotes, genomic DNA is wrapped around core histones to form nucleosomes (Olins and Olins, 2003), which are associated with various proteins that package the DNA into chromatin so it can fit inside the nucleus (Maeshima et al, 2021)
While some protein complexes are known to play a critical role in the organization of chromatin like loops that allow RNA transcription or DNA replication to be carried out, it remains unclear how chromatin is arranged into such loops
Summary
Related research article Higashi TL, Tang M, Pobegalov G, Molodtsov M, Uhlmann F. 2021. A protein complex thought to be involved in these arrangements is a ring-like structure called cohesin (Figure 1A). A recent model, called loop extrusion, suggests that genomic DNA is constantly pushed out through the cohesin ring to form loops (Davidson and Peters, 2021).
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