The longest known interval between commencement of intravenous infusion of gabexate mesilate and the development of a hand cyst

Abstract

A 4-year-old Japanese girl received a continuous infusion of gabexate mesilate (200 mg/25 ml 5% glucose) for 6 days via a peripheral vein for the treatment of hemolytic uremic syndrome. After administration, pigmentation was seen at the needle entry point on her right hand. Six years later, an elastic, hard subcutaneous mass was noted around this pigmentation. The tumor was encapsulated and partially adherent to the tendon of the extensor digitorum muscle. Histological examination revealed a membranous structure consisting of fibrous tissue containing many inflammatory cells. This was considered to be a side effect of gabexate mesilate.