Abstract
BackgroundLow-magnitude mechanical stimulation (LMMS) may improve skeletal health. The objective of this research was to investigate the long-term residual effects of LMMS on bone health. 10-week old female mice were given LMMS for 8 weeks; SHAM did not receive LMMS. Some groups remained on study for an additional 8 or 16 weeks post treatment (N = 17).ResultsEpiphyseal trabecular mineralizing surface to bone surface ratio (MS/BS) and bone formation rate (BFR/BS) were significantly greater in the LMMS group compared to the SHAM group at 8 weeks by 92 and 128% respectively. Mineral apposition rate (MAR) was significantly greater in the LMMS group 16 weeks post treatment by 14%.Metaphyseal trabecular bone mineral density (BMD) increased by 18%, bone volume tissue volume ratio (BV/TV) increased by 37%, and trabecular thickness (Tb.Th.) increased by 10% with LMMS at 8 weeks post treatment. Significant effects 16 weeks post treatment were maintained for BV/TV and Tb.Th. The middle-cortical region bone volume (BV) increased by 4% and cortical thickness increased by 3% with 8-week LMMS.ConclusionsLMMS improves bone morphological parameters immediately after and in some cases long-term post LMMS. Results from this work will be helpful in developing treatment strategies to increase bone health in younger individuals.
Highlights
Low-magnitude mechanical stimulation (LMMS) may improve skeletal health
All mice survived according to the study completion time posts, and were scanned (MicroCT) and histology performed as described in the methods
Distal epiphysis trabecular ROI In the distal epiphyseal trabecular region, there were no significant differences between LMMS and SHAM at 8 weeks
Summary
Low-magnitude mechanical stimulation (LMMS) may improve skeletal health. The objective of this research was to investigate the long-term residual effects of LMMS on bone health. 10-week old female mice were given LMMS for 8 weeks; SHAM did not receive LMMS. Osteoporosis is a common degenerative bone disease and is characterized by a net loss of bone, e.g., when bone is resorbed more quickly than it is formed It primarily affects the elderly and is most common in women. As an alternative to drug therapy, whole body vibration (WBV) may improve skeletal health without potential side effects from drugs such as osteonecrosis of the jaw [10] This therapy is administered through standing on an oscillatory platform that delivers low Bodnyk et al Journal of Biological Engineering (2020) 14:9 intensity vibration (LMMS). These signals may drive hematopoietic stem cells (HSC) to differentiate into immune cells rather than osteoclasts [12] This combination of increasing osteoblasts and decreasing osteoclasts could contribute to bone formation and improved skeletal health [12]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
