Abstract
ABSTRACT Protein undernutrition affects inter alia blood parameters and immune system. These negative effects may be improved by the addition of vitamin B6 to the diet. Here, we evaluated the effect of vitamin B6 supplementation and physical exercise in rats fed a protein-deficient diet. Rats were divided into six groups: exercised or unexercised – control, protein deficient, protein deficient with vitamin B6 supplementation. Sixty days of protein malnutrition caused significant changes in the rat body weight, haematological parameters (mainly red blood cells parameters), immunological parameters (NK and NKT cells) and biochemical parameters (total protein and albumin concentration and activity of AST). The rat exercise did not intensify the negative effects of protein malnutrition. The vitamin B6 supplementation in protein-deficient groups significantly improved body weight and red blood cell parameters. These results indicate that vitamin B6 should be considered as a valuable supplement for individuals suffering from protein malnutrition.
Highlights
According to the definition by the World Health Organization (2017), the malnutrition includes deficiencies, excesses or imbalances in the intake of energy and/or nutrients
There was a significant increase in WBC in groups of exercised rats fed protein-deficient diet (IV, mean 16.6 × 103/μL, p < .05) in compression to the other groups (I, II, III, V, VI)
We examined the effect of protein deficiency diet (4.5% of protein) on selected biochemical, haematological and immunological blood parameters in rats subjected or not subjected to the physical exercise
Summary
According to the definition by the World Health Organization (2017), the malnutrition includes deficiencies, excesses or imbalances in the intake of energy and/or nutrients. The better understanding of the effects of malnutrition may help to extenuate negative consequences of poor and unbalanced diet (Odermatt, 2011) and will be helpful in choosing controlled and limited nutrition for treatments of various disorders, such as metabolic disorder or cancer. One such nutrition-deficient diets is the protein-deficient diet. The longterm malnutrition caused negative health effects, such a reduced body weight, reduced cell number in tissues and organs, modified fatty acids’ content and affected selected blood parameters, especially in young, growing subjects (Lewicka et al, 2017; PrestesCarneiro et al, 2006). The long-term physical activity may increase negative consequences of the protein-deficient diet (Fontana, Klein, & Holloszy, 2006)
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