Abstract
The eyes are exposed to aggressive environmental influences. The blood-ophthalmic barrier is one of the resistance mechanisms serving to protect the body. Mechanical eye trauma violates the integrity of the hematoophthalmic barrier and induces oxidative stress on the background of general inflammatory process with cellular structures disturbances. The aim of our study was to investigate the peculiarities of free radical processes and antioxidant protection of the organism under induced oxidative stress by mechanical eye injury. The experiment was conducted on males of six months of age in an amount of 150. In blood, liver, brain, heart and skeletal muscle tissues we studied the state of enzyme indicators of oxidative stress in the dynamics in intact animals and in rats with violation of the blood-ophthalmic barrier by mechanical eye injury and different types of therapy. Based on the data obtained, we performed an integral assessment of oxidative homeostasis in injured animals using a logistic model. The resulting logistic regression equations allow modifying the redox processes in the body by applying biologically active compounds as additional therapy, but are of more fundamental than practical interest, as they illustrate the interrelationships of lipid peroxidation-antioxidant system enzymes in the tissues under study.
Highlights
The visual analyzer due to its structure is constantly exposed to aggressive environmental influences, primarily related to the spectral characteristics of sunlight, inducing increased formation of singlet oxygen forms, causing in turn the destruction of lipids, proteins, DNA cells [1,2,3]
In the body there are always oxidative processes induced by free radicals and it is necessary for metabolism, respiration, immune reactions, but all this is balanced by repair processes thanks to endogenous and exogenous antioxidants [11, 12]
When inflammation increases the number of free radicals and oxidation processes exceed the reduction reactions, which leads to increased destruction of injured cellular structures, but the whole and this disrupts the normal activity of the entire body
Summary
The visual analyzer due to its structure is constantly exposed to aggressive environmental influences, primarily related to the spectral characteristics of sunlight, inducing increased formation of singlet oxygen forms, causing in turn the destruction of lipids, proteins, DNA cells [1,2,3]. The blood-ophthalmic barrier is one of the resistance mechanisms, serving to protect the body and prevent homeostasis disruption when the body is exposed to factors that can disrupt this balance. It is responsible for regulating the inflow into and out of the eye of various substances characteristic of normal and pathological metabolism, and has an immune function, preventing the entry of microorganisms, antibodies and leukocytes [6,7,8]. In the body there are always oxidative processes induced by free radicals and it is necessary for metabolism, respiration, immune reactions, but all this is balanced by repair processes thanks to endogenous and exogenous antioxidants [11, 12]. When inflammation increases the number of free radicals and oxidation processes exceed the reduction reactions, which leads to increased destruction of injured cellular structures, but the whole and this disrupts the normal activity of the entire body
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