Abstract
Phorbol ester acetate was produced by the esterification of the free hydroxyl of phorbol ester C (the tumor promoting agent from croton oil). The phorbol ester acetate was used to promote skin tumors in female mice that had previously received a subcarcinogenic dosage of 7,12 DMBA. The morphology of the tumor revealed an epidermal hyperplasia as well as a hyperkeratosis of the stratum corneum. There was a marked increase in the intercellular space in the strata basale and spinosum. These cells also demonstrated an increase in ribosomes and polysomes. Many of the mitochondria of these cells revealed intramitochondrial granules that resembled lipid droplets. Phorbol ester- 14 C acetate was prepared by acetyl-2- 14 C esterification of the free hydroxyl of the phorbol ester C. The phorbol ester- 14 C acetate was applied to papillomas that were initiated with 7,12 DMBA and promoted with phorbol ester acetate for 90 days. Grains due to the phorbol ester- 14 C acetate were observed overlying the loose chromatin of the nuclei and tonofibrils.
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