The localization of octoiodofluorescein-I131 in human brain tumors

Abstract

The efficiency of I/sup 131/-labeled, octoiodofluorescein (OIF-I/sup 131/ ) as an agent for localizing human brain tumors in situ was investigatod using a manually operated scanning device. The dye was found to produce no toxic symptoms in total doses up to 30 mg when given intravenously. Labeled OIF correctly localized the presence or indicated the absence of brain tumors in 34 of 47 (73%) patients in whom diagnoses were subsequently confirmed by surgical . methods. In 55 cases confirmed by clinical (nonsurgical) methods, 40, or 73%, were correctly detected. For the combined group of 102 patients, accuracy in localizing brain tumor with OIF-I/sup 131/ was 73%. In a comparative study between OIF-I/sup 131/i, Risa, and DIF-I/sup 131/, OIF-I/sup 131/ was found to have more favorable biological characteristics for external scanning purposes than the other 2 agents. Scanning with OIF-I/sup 131/ can be performed at any time from 2 to 48 hours after injection, the optimum time being between 5 and 24 hours. The amount of dye found in resected tumor tissue was as much as l0 times that in adjacent normal brain tissue. With the manual scanning technique employed, OIF-I/sup 131/ appears to be useful as a test for themore » external detection of brain tumors. With a more sensitive automatic scanning device there should be a higher percentage of correct results. (auth)« less