Abstract
Two years after the report of Domagk1in 1935 concerning the chemotherapeutic properties of azosulfamide, certain bacterial infections were commonly treated with sulfanilamide with excellent results. Given by mouth, by rectum or by hypodermoclysis at regular intervals, therapeutic blood and tissue concentrations could be maintained which had a definite bacteriostatic effect on certain organisms. In April 1937 Sinclair and Barker2departed radically from the usual plan of administration of sulfanilamide and for the first time made use of high local concentrations of the drug for the treatment of localized infections. They used crushed sulfanilamide tablets in dental surgery, such as for infected operative wounds in the mouth, certain extractions, compound fractures and osteomyelitis of the mandible—with good results in the prophylaxis and treatment of infections. In July 1939 Jensen, Johnsrud and Nelson3reported a series of compound fractures treated with local implantation of sulfanilamide. In this series
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