Abstract
Background: Osteosarcoma is the most common primary bone malignancy in children and adolescents. In order to find factors related to its recurrence, and thus improve recovery prospects, a powerful clinical signature is needed. Long noncoding RNAs (lncRNAs) are essential in osteosarcoma processes and development, and here we report significant lncRNAs to aid in earlier diagnosis of osteosarcoma.Methods: A univariate Cox proportional hazards regression analysis and a multivariate Cox regression analysis were used to analyze osteosarcoma patients’ lncRNA expression data from the Therapeutically Applicable Research To Generate Effective Treatments (TARGET), a public database.Results: A lncRNA signature consisting of three lncRNAs (RP1-261G23.7, RP11-69E11.4 and SATB2-AS1) was selected. The signature was used to sort patients into high-risk and low-risk groups with meaningful recurrence rates (median recurrence time 16.80 vs. >128.22 months, log-rank test, P<0.001) in the training group, and predictive ability was validated in a test dataset (median 16.32 vs. >143.80 months, log-rank test, P=0.006). A multivariate Cox regression analysis showed that the significant lncRNA was an independent prognostic factor for osteosarcoma patients. Functional analysis suggests that these lncRNAs were related to the PI3K-Akt signaling pathway, the Wnt signaling pathway, and the G-protein coupled receptor signaling pathway, all of which have various, important roles in osteosarcoma development. The significant 3-lncRNA set could be a novel prediction biomarker that could aid in treatment and also predict the likelihood of recurrence of osteosarcoma in patients.
Highlights
Osteosarcoma is a common malignant bone tumor, which is predominant in childhood and adolescence [1]
We randomly divided the 92 patients into two groups to seek and validate the prognostic long noncoding RNA (lncRNA) found in the osteosarcoma patients
Recent studies suggested that lncRNAs could be good candidates for tumor signatures as they possess high sensitivity and high specificity [26,27,28,29,30]
Summary
Osteosarcoma is a common malignant bone tumor, which is predominant in childhood and adolescence [1]. Improvements in therapeutic strategies have been achieved, the prognosis remains poor for most patients with recurrent osteosarcoma. It is imperative to identify effective and novel recurrent biomarkers and therapeutic targets for osteosarcoma. Osteosarcoma is the most common primary bone malignancy in children and adolescents. Long noncoding RNAs (lncRNAs) are essential in osteosarcoma processes and development, and here we report significant lncRNAs to aid in earlier diagnosis of osteosarcoma. A multivariate Cox regression analysis showed that the significant lncRNA was an independent prognostic factor for osteosarcoma patients. The significant 3-lncRNA set could be a novel prediction biomarker that could aid in treatment and predict the likelihood of recurrence of osteosarcoma in patients
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