Abstract
EDITORIAL article Front. Neurosci., 07 December 2012Sec. Neurogenesis Volume 6 - 2012 | https://doi.org/10.3389/fnins.2012.00176
Highlights
Neurogenesis involves the generation of newborn neuronal cells from Neural Stem Cells (NSCs) and progenitor cells in the mammalian brain
Emphasis is placed on components of miRNA biogenesis, such as Dicer, Drosha, DGCR8, Lin-28, and other related proteins involved in neurogenesis; some of which have been linked to cancer, fragile × syndrome, and nervous system disorders (Kawahara et al, 2012)
The review written by Lang and Shi highlighted the dynamic roles that miRNAs play in multiple steps of neurogenesis including: NSC proliferation, self-renewal, neuronal differentiation, maturation, and dendritic spine morphogenesis (Lang and Shi, 2012)
Summary
Neurogenesis involves the generation of newborn neuronal cells from NSCs and progenitor cells in the mammalian brain. The main steps of neurogenesis include NSC self-renewal, neural progenitor cell proliferation, neuronal commitment, migration, maturation, and integration (Shi et al, 2010). MiRNAs regulate multiple processes including: development, cell proliferation and differentiation, growth and neurogenesis (Ambros, 2004; Bartel, 2004).
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