The lipolytic effects of β3-adrenoceptor agonist. CL316,243. In isolated rat and human subcutaneous. Mesenteric and epididymal white fat cells

Abstract

Series of new trigonal bipyramidal and octahedral complexes of tin(IV) have been synthesized by the reaction of dimethyltin(IV) dichloride with 4-nitro-benzanilidethiosemicarbazone (L1H), 4-chlorobenzanilidethiosemicarbazone (L2H), 4-nitrobenzanilidesemicarbazone (L3H) and 4-chlorobenzanilidesemicarbazone (L4H). The unimolecular and bimolecular reactions of dimethyltin(IV) dichloride and monobasic bidentate ligands were carried out using microwave irradiations as the thermal energy source and the complexes so formed were characterized by elemental analysis, conductance measurements, molecular weight determinations and spectral data, viz. IR, UV–vis, 1H and 13C NMR. The complexes have also been prepared by the general thermal methods for comparison purposes. The comparison data support the synthesis using the microwave route, i.e. green chemistry route. The tin(IV) complexes show penta-coordinated structure for 1:1 complexes and hexa-coordinated for 1:2 complexes. The antifungal, antibacterial and antifertility activities have been examined and the results were indeed very encouraging.