Abstract
Standard influenza virus (A 0/PR8/34) and incomplete virus of the von Magnus type were analyzed and compared. Virus propagated under conditions of serial undiluted passage had a lower molar ratio of cholesterol-phospholipid (0.6) than did standard virus. A comparison of phospholipids revealed decreased amounts of sphingomyelin and phosphatidylcholine together with increased amounts of phosphatidylethanolamine. Fatty acid profiles of the polar lipid fractions revealed a shift toward short-chain acids and long-chain polyunsaturated fatty acids. Neutral lipids, separated by a unidimensional, two-solvent system, revealed that incomplete virus had an increased amount of glycerides with a shift toward mono- and diglycerides. Such changes would tend to alter the packing of the lipids of influenza virus and lead to a more expanded and fluid envelope—accounting for the pleomorphism and defects in the envelope of the von Magnus type virus.
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