Abstract
AbstractThe photosensitizing activities of hematoporphyrin, Cu‐hematoporphyrin, protoporphyrin. Zn‐protoporphyrin, deuteroporphyrin and uroporphyrin are studied. The relative yields of 1O2 are measured in buffer (pH 8.0) and compared to the yields of Type II photodamages induced on cholesterol embedded in egg lecithin liposomes. Results show that the solubilization of the sensitizer in the lipid bilayer is a prerequisite for its photosensitizing activity at the membrane level. In this context, the partition coefficient represents an important parameter.
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