Abstract
This study aimed to demonstrate the link between the inflammatory process, cardio-metabolic risk factors and echocardiogra phy data in type 2 diabetic (T2D) patients. A total number of fifty-two patients (12 male and 40 females) with a median age of 57 year were enrolled in this study. Anthropometric measurements that related to the cardio-metabolic risk factors and blood pressure were measured. Fasting serum glucose, lipid profiles and soluble interleukin -2 receptor (sIL-2R) using the technique of enzyme linked immunnosorbent assay (ELISA) were determined. The patients categorized according to the presence of metabolic syndrome components using the National Cholesterol Education program (NCEP) definition. Echocardiography data that related to systolic and diastolic left ventricular dysfunction were recorded using B-mode ultrasound with a frequency of 2-4MHz. There was non-significant difference in echocardiography data that related to systolic and/or diastolic dysfunction and the cardio-metabolic risk factors. The mean serum sIL-2R level was 3.469±3.062 pg/ml (range: 1.316-12.5); it inversely and non-significantly correlated with ejection fraction (r = - 0.12) and atherogenic index (r=-0.148). There is a link between the left ventricular systolic function and the circulating sIL-2R in asymptomatic T2D, which does not relate to the components of metabolic syndrome
Highlights
Interleukin-2 (IL-2) is a growth factor played a role in activation, and maturation of T lymphocytes
This study aimed to demonstrate that soluble interleukin -2 receptor (sIL-2R) level could be used to explain the association between the cardiometabolic risk factors and changes in ventricular function assessed by echocardiography in type 2 diabetes (T2D)
The results of this study demonstrate that T2D patients presented with metabolic syndrome have left ventricular dysfunction that does not relate to components of metabolic syndrome
Summary
Interleukin-2 (IL-2) is a growth factor played a role in activation, and maturation of T lymphocytes. In experimental animal model of myocardial infarction, it was observed that single injection of recombinant human interleukin-2 improved angiogenesis and preserved heart function via activation the natural killer cells and thereby contributed in vascular remodeling (6). Cardiometabolic risk factors as well as abnormal ventricular function often exited in diabetic patients. The rational of this study is to prove that inflammatory process plays a role in cardiac complications in diabetic patients presented with metabolic syndrome features. This study aimed to demonstrate that sIL-2R level (as a marker of inflammatory process) could be used to explain the association between the cardiometabolic risk factors (using the criteria of metabolic syndrome) and changes in ventricular function assessed by echocardiography in T2D
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
