The link between blood‐based biomarkers and mild cognitive impairment and Alzheimer's disease in a Panamanian sample

Abstract

AbstractBackgroundStudies on blood‐based biomarkers associated with age‐related cognitive impairment are key to improve intervention mechanisms and delay the expression of symptoms. The objective of this study was to assess the relationship between blood‐based biomarkers and mild cognitive impairment (MCI) and AD in a sample of elderly Panamanians enrolled from an outpatient geriatric service.MethodA descriptive, cross‐sectional, observational study was conducted. Participants were 84 Panamanians (controls, n=41; MCI=32; and AD=11). They were assessed with MMSE and Clock Test. Non‐fasting blood samples were collected to genotype for ApoE4 and to determine a blood‐based biomarker profile.ResultCRP levels among AD participants were significantly increased relative to MCI participants (p < 0.05). A2M levels in AD participants were significantly increased compared to normal controls (p < 0.05). SAA levels in AD participants were significantly increased when compared to MCI participants (p < 0.05).ConclusionThese results show that in the AD group CRP, A2M and SAA are significantly increased. The link between MCI and AD and inflammatory markers can produce an accurate tool that can aid in early diagnosis of AD.