Abstract
Despite high immunization rates with pertussis vaccines, clinical cases of pertussis have resurged in the United States. In the 1990s, acellular pertussis (aP) vaccines replaced whole-cell pertussis (wP) vaccines because of toxicity concerns. To assess whether the increase in pertussis cases is related to relatively lower efficacy of aP vaccines, FDA researchers compared infant baboons who had been immunized using either an aP and or a wP vaccine (at 2, …
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