The likelihood of transferring a euploid embryo after PGD-aneuploidy cycles depends not only on female age but also on the number of oocytes collected

Abstract

Introduction: Aneuploidy is the most common type of chromosome abnormality and the leading cause of implantation failure, miscarriage and congenital abnormalities. Three RCTs have already demonstrated higher clinical pregnancy rates in young good prognosis patients with single embryo transfer, but investigations in other groups are limited to observational studies. Although scientific principles of comprehensive aneuploidy screening are widely accepted, controversy remains about the clinical and, particularly, economic effectiveness of this approach (Lee et al., 2014). Thus, patients and especially advanced maternal age cases need to be informed properly regarding their realistic chances of producing euploid embryos in different clinical scenarios.