The Likelihood of Sustained Unresponsiveness Following Peanut Oral Immunotherapy is Linked to The Frequency of Granzyme B+ Memory CD8+ T Cells

Abstract

Participants successfully desensitized to peanut through the 2-year-long peanut OIT trial POISED were classified as sustained unresponsive (SU) vs. desensitized alone (DS) based upon oral peanut challenge outcome following a 3-month peanut avoidance period post-OIT. Mass cytometry-based phenotyping of PBMCs from these participants showed that a lower frequency of naïve CD8+ T cells positively associates with sustained unresponsiveness. We further probed CD8+ T cells from SU and DS participants to understand molecules and pathways influencing peanut tolerance.