Abstract
A combination of two single-molecule techniques has revealed new tertiary interactions in the TPP riboswitch.
Highlights
Related research article Duesterberg VK, Fischer-Hwang IT, Perez CF, Hogan DW, Block SM. 2015
Riboswitches are regions in the non-coding regions of messenger RNA molecules that control the expression of the mRNA by sensing and binding to specific small ’ligand’ molecules
In eLife, Steven Block and co-workers from Stanford University – Van Duesterberg, Irena Fischer-Hwang, Christian Perez and Daniel Hogan – combine two single-molecule techniques to investigate the structural changes that occur in the thiamine pyrophosphate (TPP) riboswitch as it unfolds and binds to TPP and other ligands (Duesterberg et al, 2015)
Summary
Related research article Duesterberg VK, Fischer-Hwang IT, Perez CF, Hogan DW, Block SM. 2015. In eLife, Steven Block and co-workers from Stanford University – Van Duesterberg, Irena Fischer-Hwang, Christian Perez and Daniel Hogan – combine two single-molecule techniques to investigate the structural changes that occur in the thiamine pyrophosphate (TPP) riboswitch as it unfolds and binds to TPP and other ligands (Duesterberg et al, 2015). Force-extension curves can be obtained by stretching individual riboswitches and measuring the end-to-end length of the molecule (Greenleaf et al, 2008).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
