Abstract
Although the Langerhans cells were detected more than a century ago, it has only recently been realized that they belong to a family of cells, here referred to as dendritic leukocytes (DL), continuously seeded out from the bone marrow to most tissues in the body. Our knowledge about the natural life history of DL and their participation in inflammatory reactions is still fragmentary. A review of their life history and kinetics might therefore seem premature. However, during the last few years this family of cells has received widespread attention as accessory cells for the initiation of T-cell responses. A volume on the cellular kinetics of the inflammatory reaction would therefore be incomplete without a chapter devoted to these cells. Because many of the readers may not be well acquainted with this cell family, I shall first give some background information about the historical development of the dendritic leukocyte concept, and about the proposed functional roles of these cells.
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