The “Levine effect” and the father of modern diabetes research

Kenneth T Farabaugh

doi:10.1016/j.jbc.2021.101356

Abstract

The “Levine effect” and the father of modern diabetes research

Highlights

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record
The first theory of the mechanism of action of insulin was put forth by Vilém Laufberger in 1924, namely that insulin acted covalently on enzymes to directly block the process of gluconeogenesis, and thereby prevented the body from producing excess glucose to circulate in the blood [1, 2]
This theory dominated the field for a number of years, and the established researchers took for granted that insulin and glucose were freely able to diffuse into cells

Summary

Introduction

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. The first theory of the mechanism of action of insulin was put forth by Vilém Laufberger in 1924, namely that insulin acted covalently on enzymes to directly block the process of gluconeogenesis, and thereby prevented the body from producing excess glucose to circulate in the blood [1, 2].

Results

Conclusion