Abstract

目的:研究急性白血病发生发展不同阶段的端粒酶活性水平,探讨端粒酶活性检测对急性白血病的临床意义.方法:选取初治、治疗中和完全缓解期共33例成人急性白血病病例,以缺铁性贫血(IDA)和骨髓形态学正常的非血液病患者作对照,采用改良TRAP-银染法及亚利恩凝胶成像系统分析检测其骨髓标本内的端粒酶活性水平并随访.结果:缺铁性贫血患者端粒酶阴性或低水平表达;急性白血病患者端粒酶活性明显增高(P＜0.05),阳性率达70%;白血病完全缓解后端粒酶活性水平下降(P＜0.05),完全缓解期端粒酶活性仍高于正常者往往预后不良.结论:端粒酶与急性白血病的发生发展密切相关.端粒酶活性的检测可以作为白血病诊断及病情监测的一个生物学指标,有希望成为一种监测微小残留病的新的生物学标记.对白血病的抗端粒酶疗法有潜在的价值.

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