Abstract
The levels of protein C (PC) and protein S (PS) were assessed in plasmas derived from 39 patients with various chronic liver diseases and found to be significantly decreased. These decreased levels were positively correlated with the parameters for the protein synthesis in the liver, including cholinesterase, serum albmin, and hepaplastin test, suggesting that the synthesis of PC and PS were also decreased in these diseases. Interestingly, the patients with increased levels of T·AT and manifested decreased PC and PS levels in plasma. These inverse correlations seem to indicate that the decreased levels of PC and PS in plasma could precipitate the disseminated intravascular coagulation syndrome by virtue of insufficient regulation of accelerated blood coagulation.
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