Abstract
The effect of Anovlar Lyndiol 2.5 Ortho-Novin Volidan and mestranol on the plasma levels of free and conjugated 17-hydroxycorticosteroids were studied in blood samples taken from 101 women about Day 15 of the menstrual cycle and on Day 217 of treatment. Mean free 17-hydroxycorticosteroids in the morning rose significantly (p .05) similar to the increase of free hydroxycorticosteroids at the end of the last trimester of pregnancy. Evening levels of free and conjugated hydroxycoricosteroids also rose signifcantly (ps < and .001 respectively) indicating that oral contraceptives do not seem to alter the diurnal rhythm of free 17-hydroxycorticosteroids although it leads to plasma retention of these substances. Prolongation of contraceptive intake resulted in higher free 17-hydroxycorticosteroid and lower conjugated 17-hydroxycorticosteroid levels in the samples taken in the evening (p < .01).
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