The level of serum tumor necrosis factor α and its soluble receptor I and II in children with asthma

Abstract

Objective To study the roles of serum tumor necrosis factor-ix（ TNF-ct）, sTNFR- I and sT- NFR- I1 in asthmatic children. Methods The levels of serum TNF-α, sTNFR- I and sTNFR- II in 60 asthmatic children,including 30 cases of acute exacerbation group and 30 cases of clinical paracmasia group, and 22 cases of healthy children（ control group） were detected by ELISA. Results （ 1 ） The level of serum TNF-α in acute exacerbation group was （98.87 ± 16. 25 ） ng/L, it is significantly higher than the clinical paracmasia group （62. 19 ± 15.85） ng/L and control group （44. 25 ± 10. 44） ng/L （ F = 94.78, P 〈 0. 05 ）. The level of serum sTNFR- I and sTNFR-11 in acute exacerbation group were （11.14 ± 2.04） μg/L and （11.81 ± 2. 14）μg/L re- spectively,they were significantly higher than their own clinical remission group （8.91 ± 1.63 ） μg/L and （9.36 ＋ 1.72 ） μg/L, also significantly higher than the control group （ 5.03 ± 1.18 ） μg/L and （ 5.21 ±1.23 ） μg/L, （ F = 83.03 and 87. 62, all P 〈 0.05 ）. The levels of TNF-a, sTNFR- I and sTNFR- II in clinical paracmasia group were significantly higher than that in control group （ P 〈 0. 05 ）. （ 2 ） The levels of sTNFR- I and sTNFR- 11 in asthmatic children, both acute exacerbation and clinical paracmasia, were positively correlated（ r = 0. 908, P 〈 0.05 and r = 0. 737, P 〈 0. 05 ）. Conclusion The level of TNF-ot maybe indicate the inflammato- ry severity of asthma, and the changes of serum sTNFR- I and sTNFR- IIwere closely related with asthmatic air- way inflammation. Key words: Asthma; TNF-α; sTNFR- I ; sTNFR- II