The Level of Copper in Hair Androgenic Alopecia

Wiwiek Amriyana Saputri

doi:10.11648/j.ajcem.20160404.12

Wiwiek Amriyana Saputri

Open Access

https://doi.org/10.11648/j.ajcem.20160404.12

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Abstract

Androgenic alopecia is characterized by progressive loss of hair from the scalp. This research aimed to determine the hair and blood copper levels in men with androgenic alopecia. The research was conducted in the Department of Dermatovenereology of Dr. Wahidin Sudirohusodo Hospital, Makassar and the Center for Health Laboratory, Makassar, using the observational research method. The samples comprised 21 the males with androgenic alopecia and 11 control samples without androgenic alopecia. The hair and blood of the samples were analyzed using the atomic absorption spectrophotometer receipts. The research results indicated resources that the hair copper level in the androgenic alopecia group Showed a difference compared to the hair copper levels in the control group, though the difference was significant (p <0.05). On the other hand, the blood copper levels in androgenic alopecia group had no difference compared to that in the control group. The hair copper levels had no correlation with the blood copper levels. The age had a significant correlation with the androgenic alopecia, in that, the alopecia incidence would increase of as the age increased (p <0.05). However, the levels of both the hair and blood coppers had no correlation with the age. Neither, did the levels of both copper hair and blood have a correlation with the degree of androgenic alopecia (Hamilton grade).

Highlights

Androgenic alopecia is a form of hair loss is most often in men, but can occur in women, involving the loss of real hair, pigmented terminal hair on the head, which responds to circulating androgens
There were no differences in blood copper levels between androgenic alopecia and control
Hair copper levels are not related to blood copper levels

Summary

Introduction

Androgenic alopecia is a form of hair loss is most often in men, but can occur in women, involving the loss of real hair, pigmented terminal hair on the head, which responds to circulating androgens. In many developing countries androgenic alopecia when not accompanied by abnormal health status, is seen as a cosmetic problem, especially in males, but the psychological impact is not diminished. This is seen as a cosmetic issue perhaps because compared to many other issues are more pressing (e.g. socioeconomic). There is no significant difference in the levels of zinc, iron, and copper serum between patients with alopecia and normal people. DHT among others cause damage to the hair follicle that leads to an inflammatory reaction to the scalp and hair follicle miniaturization development This may be a receptor pathway abnormalities that arise. The receptor problem is probably in the fact that many subjects using chemical elements that reduce levels of DHT to occur alopecia, this may indicate involvement / disorder biochemical components in addition to testosterone and its derivatives in the pathogenesis of alopecia. [1]

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