The level of bone metabolism in patients with dental implants

Abstract

The aim of the study was to determine the activity of alkaline phosphatase (AP), tartrate-resistant acid phosphatase (TRAP) and osteocalcin in oral fluid (OF) in patients with dental implants. Dental intraosseous implantation was performed in 164 patients, aged 45 to 60 years (mean age 54.6±4.17 years), 78 (47.6%) males and 86 (52.4%) females. In 75.6% of patients more than 3 teeth were absent. A total of 641 screw intraosseous implants of the MIS system were installed. Studies were performed prior to implant placement, at 7, 14, 21 days and 3 and 6 months. The control group consisted of 20 volunteers of comparable age, 9 (45.0%) males and 11 (55.0%) females. An increased activity of AP and TPAP was revealed, but the activity change of AP in comparison with the control group was not statistically significant. Activity of TRAP in patients before implantation was higher than in controls by 40.5% (p<0.05) in group without complications and by 61.9% (p<0.05) in patients with mucositis. After implantation, the activity of TPAP remained elevated for 6 months, the maximum activity was observed after 14 days and was 3 times higher than at baseline (p<0.01). The amount of osteocalcin increased, especially in the complicated course after the implantation. The highest values of osteocalcin were observed 14 days after implantation. Determination of the activity of TPAP in the OF after implantation can be used as an indicator of the state of bone metabolism.