The Level of 25-Hydroxy Vitamin D3 in Gingival Crevicular fluid and Serum Pre-Post Scaling and Root Planning in Chronic Periodontitis Patients in Western Libya: Comparative Study

Abstract

Despite the critical role of vitamin D in the body, it can be affected by several factors that may cause deficiency and imbalances in vitamin D levels. The study aimed to evaluate 25-Hydroxy vitamin D3 in chronic periodontitis patients. The total study participants were 40 patients. They were divided into (20) as a study group with moderate to severe chronic periodontitis, and (20) chronic gingivitis patients were chosen as a control group. Gingival crevicular fluid and serum samples were collected at baseline and six weeks after therapy for the study group and at baseline for the control group. Systemic and local levels of 25-hydroxy vitamin D3 were measured using an enzyme-linked immunosorbent assay (ELISA) technique. The study group of diseased patients received initial periodontal therapy (SRP). The study showed that respective local 25-Hydroxy vitamin D3 levels significantly increased from baseline up to six weeks after (SRP) (3.41ng/ml versus 4.57ng/ml), P=0.022. The respective systemic 25-Hydroxy vitamin D3 levels significantly increased after six weeks from SRP (39.88ng/ml versus 41.48 ng/ml), P=0.001.