Abstract
One of the most striking examples of local aggregations of mast cells is found in urticaria pigmentosa, the cutaneous manifestation of mastocytosis. The significance of histamine in the phenomenon of the characteristic whealing of the macules and papules of this disease was suggested by the fundamental studies of Lewis and Grant (1). Recently high skin histamine values in urticaria pigmentosa have been reported by several workers (2, 3, 4.) Mast cells (5) and blood basophils (6) contain histamine. Eosinophils have been suggested to be involved in histamine inactivation (7).
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