Abstract
A recently introduced assay of cell mediated immunity and humoral inhibitory factors has been evaluated in colorectal cancer patients. Using a perchloric acid extract of adenocarcinoma of the large bowel as antigen, 16/27 patients with colorectal cancer had significant cellular reactivity when their separated peripheral leucocytes were tested in homologous AB serum. In autologous serum only 7/27 had significant reactivity; 6/20 patients with a variety of other malignancies showed sensitization to the colorectal antigen preparation. It is concluded that the leucocyte adherence inhibiton test may offer a simple method of assaying for serum blocking factors in sequential studies but will be of little value in the diagnosis of large bowel cancer.
Highlights
It is concluded that the leucocyte adherence inhibition test may offer a simple method of assaying for serum blocking factors in sequential studies but will be of little value in the diagnosis of large bowel cancer
This study has confirmed that the interaction between human leucocytes from patients with colorectal cancer and an extract of pooled colorectal tumours causes a reduced adherence of the cells to a glass surface
A humoral inhibitory effect of autologous sera was present in 10/16 patients who showed reactivity when tested in homologous AB serum. This is analogous to the serum blocking factors reported using the lymphocyte cytotoxicity techniques (Hellstrom et al, 1971b) and might represent one means by which the cellular immunological effects of sensitized leucocytes might be inhibited in vivo in the cancer patient
Summary
It is concluded that the leucocyte adherence inhibition test may offer a simple method of assaying for serum blocking factors in sequential studies but will be of little value in the diagnosis of large bowel cancer. The 1970; Guillou and Giles, 1973) have been present study was an attempt to evaluate used to show specific cell mediated im- this potentially useful test in a group of munity to tumour associated antigens in a 27 patients with colorectal cancer. The control subjects exhibited little or no reduced adherence in the presence of the tumour extract either in homologous
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