Abstract
The i.p. lethal activity of THC following single dose administration was significantly enhanced by pretreatment with SKF 523-A (30.0 mg/kg) or chloramphenicol (100.0 mg/kg) as evidenced by a significant reduction in the LD 50 value. Moreover, the onset to lethality was also sharply reduced. These results are discussed in light of the present knowledge concenring the metabolism of THC.
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