Abstract
Breast cancer incidence and the prevalence of obesity have considerably increased in Mexican women. The LEP G-2548A polymorphism has been associated with obesity and breast cancer risk in several ethnic populations. We hypothesize that G-2548A LEP polymorphism could be associated with breast cancer risk in women Mexican population. A total of 319 women were included in this study, 130 breast cancer patients and 189 control women. The data collected included anthropometric measurements and menopausal status, and a blood sample was obtained to evaluate SNPs using a PCR-RFLP analysis. No statistically significant associations were identified between breast cancer risk and the LEP G-2548A polymorphism in obese or normal-weight subgroups regardless of menopausal status. Our findings suggest that the LEP G-2548A polymorphism is not associated with breast cancer risk in obese western Mexican women. Our results indicate that, for western Mexican women, the LEP G-2548A polymorphism does not affect breast cancer susceptibility in obese or normal-weight subgroups regardless of menopausal status.
Highlights
Leptin is a multifunctional adipokine produced primarily by white adipose tissue
A lower frequency of the homozygous genotype AA was observed in normal-weight breast cancer patients (14%)
There was no significant relationship between the LEP G-2548A polymorphism and breast cancer risk regardless of menopausal status (Table 3)
Summary
Leptin is a multifunctional adipokine produced primarily by white adipose tissue. Recent in vitro studies have shown that leptin stimulates breast cancer growth [3] and that leptin and the leptin receptor are overexpressed in breast cancer tissue and lymph node metastases [4,5]. Mammes et al were the first to report an association between the LEP G-2548A polymorphism and overweight and variations in leptin levels [6]. Obesity is a well-established risk factor for postmenopausal breast cancer [7], and the prevalence of obesity in Mexican adults has increased markedly [8]. We hypothesised that the LEP G-2548A polymorphism is associated with breast cancer risk in Mexican women. We evaluated obese and normal-weight breast cancer patients for the LEP G-2548A polymorphism
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