Abstract
Menopause is associated with adverse changes in coagulation homeostasis. We aimed to investigate the association between objectively measured sedentary behavior (SB) and SB bouts (i.e., number and length of SB bouts) vs. fibrinogen levels in post-menopausal women. Fifty-three post-menopausal women (age 59.8 ± 6.2 years, BMI 27.3 ± 4.4) wore a multisensory device (Sensewear Mini Armband, BodyMedia, Inc., Pittsburgh, PA) for 5 days, to measure SB and physical activity (PA). Blood samples were collected to measure serum fibrinogen. Fibrinogen was directly correlated with SB (r = −0.48, p < 0.01), lying down during awake time (r = −0.50, p < 0.01), and both medium (11–30 mins) and very long bouts (>1 h) of SB (r = −0.59, p < 0.01; r = −0.51, p < 0.01, respectively), and inversely correlated with moderate to vigorous-intensity physical activity (r = −0.39, p < 0.01). Furthermore, fibrinogen was also directly correlated with BMI (r = −0.28, p < 0.05). In postmenopausal women without prevalent cardiovascular disease, the number of prolonged and uninterrupted sedentary bouts is directly correlated with increased fibrinogen levels, regardless of PA and BMI. This result suggests the importance of delivering new strategies to counteract the increase of sedentariness and inactivity of the postmenopausal population.
Highlights
In recent years, sedentary behavior (SB) has emerged as a new, independent behavioral risk factor for many noncommunicable diseases (NCDs) [1,2]
Since it was well recognized that the efficacy of MIPA may be higher when accumulated in bouts of at least 10 minutes [29,30], we focused on the number of physical activity (PA) bouts of at least
Most of the awake time was spent in sedentary pursuits and light-intensity physical activities (LIPA) (Table 1)
Summary
Sedentary behavior (SB) has emerged as a new, independent behavioral risk factor for many noncommunicable diseases (NCDs) [1,2]. SB differs from physical inactivity, which represents the failure to achieve recommended levels of physical activity (PA). An individual can be physically active, but still spending a large amount of daily time in SB. PA is a powerful protective tool against the onset and progression of most NCDs, there is evidence that SB determines harmful effects through mechanisms acting independently of PA levels [6]. Pooled data from more than one million individuals showed higher mortality in active people with a high amount of SB than in non-active people with a lower
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