Abstract
Leishmaniasis is the neglected disease among parasitic diseases with an increasing rate of infections. Recently, numerous studies have been conducted on the leishmanicidal properties of various essential oils (EOs). In this research, literature have been systematically reviewed, from 20 years ago, and required information have been extracted. Overally, leishmanicidal effects of ~180 EOs against promastigotes of nine species of Leishmania havebeen documented. Inhibitory concentrations 50% (IC50) of around 30 EOs were less than 10 μg.mL-1. EOs of Tetradenia riparia, Nectandra hihua, and Thymus hirtus with IC50s of 0.01,0.20, and 0.25 μg.mL-1 against Leishmania amazonensis, Leishmania infantum, and Leishmania major respectively, were identified as the most effective EOs. Furthermore, IC50 of Thymus hirtus on Leishmania infantum was 0.43 μg.mL-1. Frequently, substantial differences were found between the observed IC50s of one EO against promastigotes of different species of Leishmania. It can be concluded that the leishmanicidal activity of EOs is selective. Turning to the results,the combination of EOs for the design of multifunctional drugs can lead to excellent outcomes.Interestingly, the results have been classified by promastigote species, so this would be a valuablebenchmark for researchers.
Highlights
Leishmaniasis is one of the most important vectortransmitted diseases which has the second rank after malaria in terms of mortality caused by a parasite disease [1]
Substantial differences were found between the observed Inhibitory concentrations 50% (IC50) of one essential oils (EOs) against promastigotes of different species of Leishmania
Implication for health policy/practice/research/medical education: This review provided a detailed insight into the leishmanicidal activities of around 180 plant-derived essential oil and showed that some of them could be used as a reliable source for developing new drugs or nano/formulations
Summary
Leishmaniasis is one of the most important vectortransmitted diseases which has the second rank after malaria in terms of mortality caused by a parasite disease [1]. The LCA of EOs on different types of promastigotes systematically have been reviewed, form January 1, 2000 to June 30, 2019. Leishmanicidal activity of essential oils LCA of 179 EOs on promastigotes of 9 species of Leishmania was extracted from 66 documents.
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