Abstract

This article highlights the scientific achievements, professional career, and personal interactions of Malcolm B. Segal who passed away in July this year. Born in 1937 in Goodmayes, Essex, UK, Segal rose to the Chairman position in the Division of Physiology at United Medical and Dental School of Guy’s and St. Thomas’ Hospitals, retiring in 2006 after his long professional career in biomedical science. Being trained in Hugh Davson’s laboratory, Segal became one of the pioneers in research on cerebrospinal fluid physiology and the choroid plexus. During the course of his career, Segal himself trained a number of young scientists and collaborated with many colleagues around the world, making long-lasting friendships along the way. In addition to his professional accomplishments as a researcher and educator, Segal was an avid sailor and wine connoisseur, and enjoyed teaching classes on navigation and wine tasting.

Highlights

  • This article highlights the scientific achievements, professional career, and personal interactions of Malcolm B

  • Malcolm was a pioneering figure in the field of cerebrospinal fluid (CSF) physiology for many decades, with deep expertise in the dynamics of brain fluids and the diverse functions of the choroid plexus/blood-CSF barrier (BCSFB)

  • While the methods that Malcolm had initially used in Davson’s laboratory were valuable, they did not allow the investigator to discriminate between the transport processes at the choroid plexus/BCSFB from those at the blood–brain barrier (BBB)

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Summary

Introduction

This article highlights the scientific achievements, professional career, and personal interactions of Malcolm B. Malcolm was a pioneering figure in the field of cerebrospinal fluid (CSF) physiology for many decades, with deep expertise in the dynamics of brain fluids and the diverse functions of the choroid plexus/blood-CSF barrier (BCSFB).

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