Abstract
We report that the activation of porcine peripheral blood lymphocytes (PBL) by ectin concanavalin A (Con A) led to the increase in tyrosine phosphorylation on 84-, 72-, 55-, 40-, and 33-kDa proteins. A non-receptor protein-tyrosine kinase (PTK), p72 syk (Taniguchi et al. (1991) J. Biol. Chem. 266, 15790-15796), was detected in PBL around 0.1 % of total protein and distributed in both particulate and cytosolic fractions. Furthermore, Con A induced a rapid activation of p72 syk within 1 min in a manner similar to the time course of Con A-induced protein-tyrosine phosphorylation. These results suggest that p72 syk plays a certain role in the activation of PBL and that p72 syk may be one of the major non-receptor PTKs in T cells as well as in B cells.
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