The layout of functional maps in area 18 of strabismic cats

Abstract

Strabismus (or squint) is both a well-established model for developmental plasticity and a frequent clinical symptom. To analyze experience-dependent plasticity of functional maps in the brain we used optical imaging of intrinsic signals to visualize both orientation and ocular dominance domains in cat area 18. In strabismic animals, iso-orientation domains exhibited a pinwheel-like organization, as previously described for area 18 of normally raised animals and for area 17 of both normally raised and strabismic cats. In area 18, mean pinwheel density was similar in the experimental (2.2 pinwheel centers per mm 2 cortical surface) and control animals (2.3/mm 2 in normally raised animals), but significantly lower than in area 17 of both normally raised and strabismic cats (2.7–3.4/mm 2). A comparison of orientation and ocular dominance domains revealed that iso-orientation domains were continuous across the borders of ocular dominance domains and tended to cross these borders at steep angles. Thus, the orientation map does not seem to be modified by experience-dependent changes in afferent activity. Together with our recent observation that strabismus does not enhance the segregation of ocular dominance domains in cat area 18, the present data indicate that the layout of functional maps in area 18 is less susceptible to experience-dependent manipulations than in area 17.