The Latest Research Progress of m6A Modification and Its Writers, Erasers, Readers in Infertility: A Review.

Xuda Liu,Zhipeng Qi,Jiashuo Li,Bin Xu,Haiying Wang,Yu Deng,Zhaofa Xu,Bingchen Liu,Wei Liu

doi:10.3389/fcell.2021.681238

Xuda Liu, Zhipeng Qi + Show 7 more

Open Access

https://doi.org/10.3389/fcell.2021.681238

Copy DOI

Abstract

Eukaryotic messenger mRNAs contain many RNA methyl chemical modifications, in which N6-methyladenosine (m6A) plays a very important role. The modification process of RNA methylation is a dynamic reversible regulatory process that is mainly catalyzed by “Writer” m6A methyltransferase, removed by “Eraser” m6A demethylase, and recognized by the m6A binding protein, thereby, linking m6A modification with other mRNA pathways. At various stages of the life cycle, m6A modification plays an extremely important role in regulating mRNA splicing, processing, translation, as well as degradation, and is associated with gametogenesis and fertility for both sexes. Normal gametogenesis is a basic guarantee of fertility. Infertility leads to trauma, affects harmony in the family and seriously affects the quality of life. We review the roles and mechanisms of RNA m6A methylation modification in infertility and provide a potential target for infertility treatment, which can be used for drug development.

Highlights

Before the appearance of obvious morphological defects, messenger RNA (mRNA) levels of undifferentiated spermatogonia were found to have been altered. These findings indicate that m6A modification mediated by methyltransferase-like protein 3 (METTL3)/methyltransferase-like protein 14 (METTL14) affects the fate of spermatogonial stem cells (SSCs) (Lin et al, 2017)
The harm caused by reproductive health and its influencing factors to humans should be urgently resolved
The mechanism involves the cooperation of METTL3 and METTL14 to control timely translation of methylation transcription, thereby, appropriately regulating the production of proteins that are necessary for spermatogenesis

Summary

Introduction

At various stages of the life cycle, m6A modification plays an extremely important role in regulating mRNA splicing, processing, translation, as well as degradation, and is associated with gametogenesis and fertility for both sexes. M6A regulates RNA gene expression and metabolism through m6A Modification in Infertility the action of methyltransferase (writer), demethylase (eraser) and m6A binding protein (reader).

Results

Conclusion