The latest progress on miR-374 and its functional implications in physiological and pathological processes.

Hongjun Bian,Yi Zhou,Yongsheng Zhang,Jianni Qi,Dawei Zhou,Deya Shang

doi:10.1111/jcmm.14219

Hongjun Bian, Yi Zhou + Show 4 more

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https://doi.org/10.1111/jcmm.14219

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Abstract

Non‐coding RNAs (ncRNAs) have been emerging players in cell development, differentiation, proliferation and apoptosis. Based on their differences in length and structure, they are subdivided into several categories including long non‐coding RNAs (lncRNAs >200nt), stable non‐coding RNAs (60‐300nt), microRNAs (miRs or miRNAs, 18‐24nt), circular RNAs, piwi‐interacting RNAs (26‐31nt) and small interfering RNAs (about 21nt). Therein, miRNAs not only directly regulate gene expression through pairing of nucleotide bases between the miRNA sequence and a specific mRNA that leads to the translational repression or degradation of the target mRNA, but also indirectly affect the function of downstream genes through interactions with lncRNAs and circRNAs. The latest studies have highlighted their importance in physiological and pathological processes. MiR‐374 family member are located at the X‐chromosome inactivation center. In recent years, numerous researches have uncovered that miR‐374 family members play an indispensable regulatory role, such as in reproductive disorders, cell growth and differentiation, calcium handling in the kidney, various cancers and epilepsy. In this review, we mainly focus on the role of miR‐374 family members in multiple physiological and pathological processes. More specifically, we also summarize their promising potential as novel prognostic biomarkers and therapeutic targets from bench to bedside.

Highlights

NcRNAs represent a newly recognized kind of transcripts that lacks an “open reading frame” (ORF).[1]
We mainly summarize the role of miR‐374 family members, a highly conserved miRNA cluster in evolution, in different physiological and pathological processes
Investigations on miR‐374 family members are relatively superficial, both physiologically and pathologically, and mainly include the detection of miR‐374 expression performed by microarrays or RT‐qPCR assays and the analysis of correlation be‐ tween miR‐374 expression and cell apoptosis, invasion, metastasis and relapse, etc

Summary

Introduction

NcRNAs represent a newly recognized kind of transcripts that lacks an “open reading frame” (ORF).[1]. Qu et al[23] more comprehensively analysed the function of miR‐374b from colon cancer tissues to cell lines.

Results

Conclusion