Abstract
The current challenge in the biological study of Neuropsychiatry - particularly, in Major Depressive Disorder - consists of avoiding exercising a reductionism in the language of psychopathology by naturalizing its symptomatology (Berrios, 2011). For this, it is essential to observe the conceptual aspects inherent to the validation of the methods applied in their study. However, it is paradoxical to recognize that, in numerous neurobiological research projects, this observation is hardly considered relevant due, fundamentally, to the heterogeneous conceptual evolution that experimental validation criteria present.
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