Abstract
Arachidonic acid (AA) induced aggregation of canine platelets can be inhibited by various phosphodiesterase inhibitors (PDIs) with the order of potency IBMX > papaverine>Ro 20-1724>theophylline. With aggregation induced by AA plus epinephrine (EPI), only IBMX and papaverine inhibited at 100 μM. None of these PDIs affected the basal cAMP levels but all potentiated the PGE 1-stimulated cAMP production, with the order of potency being Ro 20-1724>papaverine> IBMX>theophylline. PGE 1 at 1 μM caused a sharp increase in cAMP and complete inhibition of platelet aggregation induced by AA plus EPI. However, when EPI was added before PGE 1, there was no elevation of cAMP yet inhibition of aggregation still occurred. Our results indicated that inhibition of platelet aggregation does not require a measurable increase in cAMP.
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