Abstract
Background and Aims: The liver plays a central role in regulation of iron metabolism. The hepatocyte synthesizes and secretes hepcidin (hepc), a central regulator of cellular iron uptake and of intestinal iron absorption. Hepc gene expression is upregulated by acute phase mediators, mainly IL–6 synthesized during inflammatory processes. Kupffer cells (KCs) may be induced to synthesize and secrete acute phase cytokines e.g. by treatment with endotoxin. Involvement of KCs in hepatic response after iron administration has been excluded by previous treatment of animals with gadolinium chloride (GD). We analysed the influence of GD on hepc and other iron related proteins gene expression in vivo and in vitro.
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