Abstract
This study investigates the inhibitory effects of Korean mistletoe extract (KME) on adipogenic factors in 3T3-L1 cells and obesity and nonalcoholic fatty liver disease (NAFLD) in mice fed a high-fat diet. Male C57Bl/6 mice fed a high-fat diet were treated with KME (3 g/kg/day) for 15 weeks for the antiobesity and NAFLD experiments. Body weight and daily food intake were measured regularly during the experimental period. The epididymal pad was measured and liver histology was observed. The effects of KME on thermogenesis and endurance capacity were measured. The effects of KME on adipogenic factors were examined in 3T3-L1 cells. Body and epididymal fat pad weights were reduced in KME-treated mice, and histological examination showed an amelioration of fatty liver in KME-treated mice, without an effect on food consumption. KME potently induces mitochondrial activity by activating thermogenesis and improving endurance capacity. KME also inhibited adipogenic factors in vitro. These results demonstrate the inhibitory effects of KME on obesity and NAFLD in mice fed a high-fat diet. The effects appear to be mediated through an enhanced mitochondrial activity. Therefore, KME may be an effective therapeutic candidate for treating obesity and fatty liver caused by a high-fat diet.
Highlights
Obesity is the most common metabolic disorder and results from the combined effects of excess energy intake and reduced energy expenditure [1]
Our results indicate the great potential of Korean mistletoe extract (KME) as a potential metabolic regulator of adipocyte differentiation and a potential therapeutic agent for preventing or treating obesity and nonalcoholic fatty liver disease (NAFLD)
Our results show that peroxisome proliferatoractivated receptorγ (PPAR-γ), CCAAT/enhancerbinding protein-α (C/EBP-α), and SREBP1c mRNA levels were decreased by 64%, 60%, and 32%, respectively, (Figure 5(a))
Summary
Obesity is the most common metabolic disorder and results from the combined effects of excess energy intake and reduced energy expenditure [1]. It is one of the fastest growing major disorders throughout the developed nations [2]. It is associated with a variety of clinical disorders in developed nations [2]. Obesity is associated with a variety of clinical disorders, including hypertension, insulin resistance, glucose intolerance, and dyslipidemia. Long-term feeding with a high-fat diet can induce obesity with hyperlipidemia, insulin resistance, hyperphagia, and hypergluconemia [4, 5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
