The Kleine-Levin Syndrome: A Rare Disease with Often Delayed Diagnosis-A Report of Two Cases in the Department of Neurology of the University Hospital of Cocody (Côte d'Ivoire).

Berthe Assi,Constance Yapo-Ehounoud,Evelyne Aka-Diarra,Christian Tanoh,Mohamed Ben Allaoui Baby,Muriel Amon-Tanoh

doi:10.1155/2016/8929413

Berthe Assi, Constance Yapo-Ehounoud + Show 4 more

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https://doi.org/10.1155/2016/8929413

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Abstract

The Kleine-Levin syndrome is a rare pathology characterized by recurrent episodes of hypersomnia associated with behavioral and cognitive disorders with, among others, hyperphagia and hypersexuality. The disease mainly affects young males. A few studies mention cases that occurred in Africa, especially in Côte d'Ivoire. In this paper, we report the very first two cases observed in the Neurology Department of the University Hospital of Cocody. The diagnosis was clinical, based on the recurrence of hypersomnia, cognitive and behavioral disorders during the periods of hypersomnia, and the return of patients to normal state between episodes. This diagnosis was delayed due to failure to understand the pathology, thereby leading patients to wandering. In fact, the two patients were consulted, respectively, 3 years and 6 years after the hypersomnia began. The objective was to report the very first cases observed in the Neurology Department of the University Hospital of Cocody, Côte d'Ivoire.

Highlights

The Kleine-Levin syndrome (KLS) is classified among rare diseases [1, 2]
For the ICSD-3, the Kleine-Levin syndrome is a disorder characterized by recurrent episodes of hypersomnia and hyperphagia, usually with onset in early adolescence in males but occasionally in later life and in women
In reporting the very first two cases of Kleine-Levin syndrome diagnosed in our service, we aim at bringing our contribution to science

Summary

Introduction

The Kleine-Levin syndrome (KLS) is classified among rare diseases [1, 2]. It belongs to the central hypersomnias said to be recurrent and defined according to the International Classification of Sleepiness Disorders, 3rd version (ICSD-3), revised in 2014. For the ICSD-3, the Kleine-Levin syndrome is a disorder characterized by recurrent episodes of hypersomnia and hyperphagia (rapid consumption of a large amount of food), usually with onset in early adolescence in males but occasionally in later life and in women. A review of the international literature of language between 1962 and 2004, by Arnulf et al [2], estimated the number of published cases at 186 According to these authors, the annual incidence was 2.7 in 1970, 3.5 in 1980, and 5.8 in the 1990s. In reporting the very first two cases of Kleine-Levin syndrome diagnosed in our service, we aim at bringing our contribution to science

Case 1

Case 2

Discussion

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Conclusion