Abstract
The rectal absorption rates of sodium iodide and the sodium salt of 2,4,6-triiodophenol in suppository bases at various pH values and in the presence of surface-active agents and polyethylene glycol additives were determined by continuous external detection at the site of insertion. The rate of sodium iodide absorption is accelerated in the presence of surfactants and appears to be proportional to the surface tension lowering and the peptizing action of their surface active components. The rate of absorption of the phenolate is retarded by the presence of surfactants. Hydrolysis and subsequent solubilization of the free phenol is postulated to explain this effect.
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